Discovery of new AMR drugs targeting modulators of antimicrobial activity using in vivo silkworm screening systems

Drug-resistant bacteria are causing global concerns, prompting the need for new antimicrobial drugs. Strategies in drug discovery consider third factors like host-derived elements, adjuvants, and drug combinations. Silkworms are being explored for their effectiveness in evaluating ADMET and therapeutic potential. Silkworms can establish a screening method incorporating interactions with third factors, promising new pathways for identifying antimicrobial drugs with unique mechanisms of action.